LIQUID CHROMATOGRAPHY TANDEM-MASS SPECTROMETRY METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ANALYSIS OF PARACETAMOL, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, AND AMBROXOL HYDROCHLORIDE IN BULK AND IN TABLET DOSAGE FORM
نویسندگان
چکیده
منابع مشابه
Simultaneous Determination of Chlorpheniramine Maleate, Phenylephrine Hydrochloride, Paracetamol and Caffeine in Pharmaceutical Preparation by Rp-hplc
A reversed-phase High-Performance Liquid-Chromatography (RP-HPLC) method was successfully developed for the simultaneous determination of quaternary mixture consisting of chlorpheniramine maleate (CPM), phenylephrine hydrochloride (PE), paracetamol (PCM) and caffeine in pharmaceutical preparation. The method was found to be simple, sensitive and rapid. The separation of the drugs was carried ou...
متن کاملDevelopment and validation of RP-HPLC method for simultaneous estimation of nimesulide, phenylephrine hydrochloride, chlorpheniramine maleate and caffeine anhydrous in pharmaceutical dosage form.
In this study, a simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of nimesulide (NS), phenylephrine hydrochloride (PE), chlorpheniramine maleate (CPM) and caffeine anhydrous (CF) in pharmaceutical dosage forms. A reversed phase Hypersil phenyl column (4.6 mm x 25 cm) with mobile phase having pH 5.5 consis...
متن کاملreversed phase high performance liquid chromatographic method for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form
eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...
متن کاملSimultaneous Estimation of Ambroxol Hydrochloride and Loratadine in Tablet Dosage Form by Using Uv Spectrophotometric Method
A novel, simple, rapid, precise, accurate, cost effective and reproducible spectrophotometric method has been developed for simultaneous estimation of ambroxol hcl and loratadine in combined tablet dosage form. The method employs measurement of absorbance at two wavelengths,308nm and 245nm, of ambroxol and loratadine respectively. Beer ́s law obeyed in the concentration range of 1050μg/ml and 10...
متن کاملDevelopment and Validation of Dual Wavelength Uv Spectrophotometric Method for Simultaneous Estimation of Ambroxol Hydrochloride and Desloratadine Hydrochloride in Their Combined Tablet Dosage Form
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of Ambroxol Hydrochloride and Desloratadine Hydrochloride in combined tablet dosage form. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2018
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2018.v11i7.25463